Irf4 binding motif

Author: rays

August undefined, 2024

WebSep 2, 2024 · IRF4 and DNA-Binding Motifs IRF4 belongs to the IRF gene family, which encodes basic leucine zipper (bZIP)-type transcription factor proteins. bZIP proteins possess three modular functional regions: dimerization, DNA binding, and transcriptional regulation regions. WebApr 24, 2024 · The transcription factor (TF) interferon regulatory factor-4 (IRF4) promotes both germinal center (GC) reactions and plasma cell (PC) differentiation by binding to …

Feed-forward regulatory loop driven by IRF4 and NF-κB in adult T …

WebIRF4 IRF-4 is a member of the interferon regulatory factor (IRF) family of transcription factors, which were first identified as being involved in the expression of interferon-induced genes. From: The Immune Response, 2006 Related terms: CD4 IRF8 T Cells Plasma Cell Lymphoma Germinal Center Cellular Differentiation Phenotype B Cell Proteome WebDec 10, 2024 · IRF4 acts at the two key stages of pre-B cells, negatively regulating pre-B cell expansion and promoting L chain rearrangement and transcription, directly binding to Ig kappa (k) and lambda enhancer. IRF4 was originally discovered as the partner of the Ets transcription factor PU.1 in the immunoglobulin k light chain enhancer [ 5 ]. greenbelt road and aerospace road

IrF4 directly binds to nedd4 gene. A. ChIP-seq data

WebAug 1, 2024 · PU.1 bound to the CNS3 probe even when the IRF4 binding motif was mutated , probably because the remaining Ets motif in the mutated probe can be bound with monomeric PU.1. To clarify whether PU.1 binds to CNS3 by itself in living cells, we evaluated the effect of IRF4 knockdown on the binding degree of PU.1 to the EICE in CNS3 by a ChIP … WebIRF4 binding to the ISRE motif in the nedd4 gene locus was further confirmed by the conventional ChIP assay, which showed significant enrichment of IRF4 binding at nedd4 gene promoter in... WebMar 14, 2024 · The IRF4 protein acts like a switch that turns on and off some genes involved in the body’s response to infection. In patients with this mutation, the IRF4 protein does not work as it should. Guérin et al. suggest that Whipple’s disease may be caused by specific genetic mutations affecting the immune system in subjects infected by T. whipplei. greenbelt road shell towing

National Center for Biotechnology Information

IRF4 controls the positioning of mature B cells in the lymphoid ...

WebMUM1 / IRF4 is a nuclear marker that is normally expressed in activated B and T cells, plasma cells and melanocytes. Involved in the differentiation of B cells and T cells. Marker … Web(a) Motif analysis of IRF4-binding sites based on the 1,338 most significant peaks (P < 10−10); the 100-bp sequences centered on the binding summit were used for analysis; … green belts ap human geography definitionWebTo optimize motif analysis to distinguish sequence requirements of high-affinity versus a low-affinity AICEs, we needed to identify which motif(s) within a peak were functional for BATF/IRF4... green belt refresher course

"WebJan 20, 2024 · Abstract. Interferon regulatory factor 4 (IRF4) is a transcription factor (TF) and key regulator of immune cell development and function. We report a recurrent … " - Irf4 binding motif

Irf4 binding motif

Entry - *601900 - INTERFERON REGULATORY FACTOR 4; IRF4

WebAug 13, 2024 · Interferon regulatory factor 4 (IRF4) is a lymphoid transcription factor and a key regulator in the development of various immune cells, including T and B cells. It is well-known that IRF4 controls numerous decision-making processes relating to B cell … WebIRF4 is a negative regulator of TLRs and regulates the production of proinflammatory cytokines by macrophages in response to LPS and signals via complexes containing …

Did you know?

WebOct 10, 2024 · To investigate whether PDGF D has any biological functions independent of its ability to activate β-PDGFR possibly via the CUB domain, three arginine residues in the R 340 R 341 GR 343 motif within the GFD, known to be critical for its binding to β-PDGFR, were mutated to alanines (TM). 26 To purify recombinant GFD-D proteins, the CUB domain ... WebDec 18, 2009 · Genome-wide ChIP-Seq mapping of STAT3- and IRF4-binding sites showed that most regions with IL-21-induced STAT3 binding also bound IRF4 in vivo and furthermore revealed that the noncanonical TTCnnnTAA GAS motif critical in Prdm1 was broadly used for STAT3 binding.

WebMay 23, 2013 · At higher concentrations, IRF4 binding shifted to interferon sequence response motifs; these enriched for genes involved in plasma cell differentiation. Our results support a model of “kinetic control” in which signaling-induced dynamics of IRF4 in activated B cells control their cell-fate outcomes. Graphical Abstract WebMar 19, 2024 · In addition, we analyzed the distribution of DNA binding motifs within ±3 kilobase pairs (kb) from the sites bound by both IRF4 and NF-κB (Figure 2F; supplemental Table 4). As expected, both IRF and NF-κB binding motifs were enriched at the center of transcription factor binding sites.

WebMar 1, 2015 · Motif analysis of the chicken ovalbumin upstream promoter-transcription factor II DNA-binding intervals revealed an enrichment in FOXO1 motifs . The role of IRF4 in the modulation of inflammation and immune response in differentiating HESCs remains to … WebIRF4 binds to the canonical IFN-stimulated response elements (ISREs) as a homodimer, and it engages erythroblast transformation-specific IRF composite elements (EICEs) and activating protein 1...

WebApr 24, 2024 · Such diverse functions of IRF4 are thought to rely on multiple DNA binding motifs to which IRF4 binds as heterodimers or its homodimer depending on its protein level. 15 IRF4 binds the Ets-IRF composite elements (EICEs) with PU.1, 16 the AP-1-IRF composite elements (AICEs) with AP-1 family such as Batf, 17, 18, 19, 20 and the interferon sequence …

WebMacrocyclization of the ATCUN Motif Controls Metal Binding and Catalysis Inorg. Chem, 2013, 52, 2729–2735. Neupane, K. P.; Aldous, A. R. and Kritzer, J. A.* Metallopeptide … greenbelt recreation marylandWebIRF-4 was initially characterized in lymphocytes and was shown to function as both a transcriptional repressor and activator. More recently, IRF-4 expression and function have … flowers mansfield ohioWebJul 17, 2015 · The AICE motif directs assembly of IRF4 or IRF8 (601565) with BATF heterodimers and is also used in TH2, B, and dendritic cells. ... (164720) or Ap1 (165160) binding sites with Pu.1 (SPI1; 165170) or Batf (612476). At higher concentrations, Irf4 binding shifted to interferon sequence response elements, and these enriched for genes … flowers mansfield maWebApr 4, 2024 · IRF4 protects arteries against neointima formation by promoting the expression of KLF4 by directly binding to its promoter. We propose that the Irf4 locus functions as the "reader" of TCR signal strength, and in turn, concentration-dependent activity of Irf4 "writes" T helper fate choice. flowers maplewood mnWebJun 21, 2013 · BATF leucine zipper motifs interact with interferon-regulatory factor 4 (IRF4) and IRF8 at AP-1–IRF consensus elements (AICEs). The discovery of the BATF–IRF … greenbelt shooting todayWebIRF4, a member of the interferon regulatory factor (IRF) family, was previously shown to be restricted in the immune system and involved in the differentiation of immune cells. … flowers manufacturers in usaWebApr 24, 2024 · The transcription factor (TF) interferon regulatory factor-4 (IRF4) promotes both germinal center (GC) reactions and plasma cell (PC) differentiation by binding to … green belt six sigma certification near me