WebbPias1 Mouse Gene Details protein inhibitor of activated STAT 1 International Mouse Phenotyping Consortium Gene: Pias1 MGI:1913125 Not currently registered for … Webb1 juli 2016 · The protein inhibitor of activated STAT-1 (PIAS1) is one of the few known SUMO E3 ligases. PIAS1 has been implicated in several biological processes including …
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WebbGene therapy relies on the delivery of genetic material to the patient’s cells in order to provide a therapeutic treatment. Two of the currently most used and efficient delivery systems are the lentiviral (LV) and adeno-associated virus (AAV) vectors. Gene therapy vectors must successfully attach, enter uncoated, and escape host restriction factors … king fitted bottom sheets only
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To investigate the physiological function of PIAS1 in HeLa cells, we overexpressed PIAS1 (Fig. 1a) and generated a PIAS1-knockout (KO) cell line (Supplementary Fig. 1 and Fig. 1b). For the PIAS1 overexpression, the abundance of PIAS1 in HeLa cells was increased by six-fold at 48 h post transfection (Fig. 1a). PIAS1 … Visa mer To gain a better understanding of the role that PIAS1 plays in cell proliferation, migration, and motility, we modified our previously published large-scale SUMO proteomic approach to … Visa mer Next, we selected E3 SUMO-protein ligase NSE2 (NSMCE2) and prefoldin subunit 2 (PFDN2), which were identified in SUMO proteomic experiments as putative PIAS1 substrates for further validation. We performed in vitro … Visa mer VIM is predominantly found in various mesenchymal origins and epithelial cell lines35,36,37. Increasing evidence shows that VIM plays key roles in cell proliferation38, … Visa mer Interestingly, our large-scale SUMO proteomic analysis identified five SUMOylation sites on PIAS1 (Fig. 5a). Two of these sites (Lys-46 and Lys-56) are located in the SAP … Visa mer WebbThe LIM domain protein KyoT2 negatively regulates the Notch signaling pathway through interaction with RBP-J, the core element of the Notch signaling pathway in the nucleus. Here we show that PIAS1 ( Webb24 feb. 2014 · PIAS1 knockdown significantly inhibited the tumor formation of MDA-MB231 cells in both the subcutaneous and the fat pad models ( Fig. 1d ), suggesting an important role of PIAS1 in the regulation of breast tumorigenesis. PIAS1 regulates the self-renewal of breast tumor initiating cells (TICs) king fitted sheet